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The Silent Threat: Commonly Overlooked Ototoxic Substances That Can Harm Your Hearing

Dennis Cashins • October 2, 2025

Chemical Exposures That Can Harm Your Hearing

When we think about hearing loss or tinnitus, we usually point fingers at aging, loud noises, or family history. But there’s another factor that often gets ignored: ototoxicity, which refers to damage in the inner ear caused by various substances. This risk comes from a range of sources, including prescription medications, over-the-counter (OTC) drugs, and some household or industrial chemicals. Unfortunately, these ototoxic agents often fly under the radar, making many people susceptible to chronic hearing issues.


In this blog, we’ll dive into the overlooked substances that can be harmful to your hearing, including medications, common household products, and workplace chemicals. Plus, I’ll share some practical tips to help reduce their impact on your hearing health.

What Is Ototoxicity?

Ototoxicity refers to the harmful effects of certain substances on the structures of the inner ear, particularly the cochlea (responsible for hearing) and the vestibular system (responsible for balance). Exposure can lead to temporary or permanent hearing loss, tinnitus (ringing in the ears), or issues with balance. Alarmingly, many ototoxic agents lurk in everyday items and medications that we often use without a second thought. Workplace chemical use can result in ototoxic hearing loss. An industrial hygiene survey or audit should be performed by employers to make sure this risk doesn't remain unknown.


Prescription Medications: An Underappreciated Risk.

  • While prescription drugs can be essential for health, some pose a hidden risk of ototoxicity. Here are a few common offenders:


  • Aminoglycoside Antibiotics (e.g., Gentamicin, streptomycin): Often used to treat serious infections. These antibiotics can cause lasting damage to your inner ear, even at normal doses, particularly in patients with kidney issues.


  • Loop Diuretics (e.g., Furosemide): Prescribed for heart failure and hypertension. These can lead to hearing loss, especially when combined with other ototoxic drugs.


  • Chemotherapy Agents (e.g., Cisplatin): Used in cancer treatment, with Cisplatin being known for causing irreversible inner ear damage.


  • Macrolide Antibiotics (e.g., Erythromycin): Commonly used for infections, but they can cause temporary hearing loss at high doses.


  • Antimalarial Drugs (e.g., Chloroquine, quinine): These can result in hearing loss and tinnitus.


  • Salicylates (e.g., high doses of aspirin): These can lead to temporary ringing in the ears that usually resolves once the medication is stopped.


Over-the-Counter Medications: Risks in Plain Sight

  • Though OTC medications are often viewed as safe, some can be ototoxic, especially if not used correctly:


  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., Ibuprofen): Regular high-use can lead to issues with hearing due to reduced blood flow to the inner ear.


  • Acetaminophen: Frequent use might contribute to hearing loss by depleting protective compounds in the cochlea.


  • Cold and Allergy Medications (e.g., pseudoephedrine): These can restrict blood flow to the inner ear and may cause temporary tinnitus.


Household Chemicals: Hidden Dangers

  • Surprisingly, some everyday products contain chemicals that can be damaging to your hearing over time:


  • Solvents  (e.g., Toluene in paint thinners): Prolonged exposure can be linked to auditory damage and tinnitus. Always use these products in well-ventilated areas and wear proper protective gear.


  • Pesticides (e.g., Organophosphates): Chronic exposure can lead to hearing loss. It’s important to follow safety guidelines and wear protective gear while handling them.


  • Adhesives and Glues: Many of these contain harmful substances that can have similar effects on hearing.


By being informed about these ototoxic substances, we can take proactive steps to protect our hearing health. It’s crucial to talk to your healthcare provider about the risks associated with any medications you’re taking and to be mindful of the chemicals we use in our daily lives. Let's prioritize our hearing health by staying educated and cautious!


If you are concerned about this issue in your workplace, let your employer know. They can click the button below and we can help determine what the risk is.

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